NALP5 polyclonal, anti-human, mouse, rat
€484.00
In stock
SKU
254345
Protein Family: Enzymes
Pathway and Disease: Signaling Molecules and Interaction
Description:
NALP proteins include the apoptosis regulator APAF1 (apoptotic protease activating factor 1) and mammalian NOD-LRR proteins and are thought to be involved in inflammation and reproduction. NALP5, also known as MATER, is a maternal gene required for early embryonic development in mice. Increased NALP5 expression was observed in two neuronal injury models, and transient expression of recombinant NALP5 in neurons induced caspase-3 activation and apoptosis, suggesting that NALP5 also plays a role in caspase activation and apoptosis in injured neurons, and may thus represent a novel target for therapeutic treatment in neurodegenerative disorders.
Alternate Names: NALP5, NLR family pyrin domain containing 5, NLRP5, MATER, PYRIN-containing APAF1-like protein 8, PYPAF8, CLR19.8, PAN11
Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500
Accession No.: NP_703148
Antigen: KLH-conjugated synthetic peptide encompassing a sequence within human NALP5.
Format: Each vial contains 0.1 ml IgG in PBS pH 7.4 with 0.02% sodium azide. Antibody was purified by immunogen affinity chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Pathway and Disease: Signaling Molecules and Interaction
Description:
NALP proteins include the apoptosis regulator APAF1 (apoptotic protease activating factor 1) and mammalian NOD-LRR proteins and are thought to be involved in inflammation and reproduction. NALP5, also known as MATER, is a maternal gene required for early embryonic development in mice. Increased NALP5 expression was observed in two neuronal injury models, and transient expression of recombinant NALP5 in neurons induced caspase-3 activation and apoptosis, suggesting that NALP5 also plays a role in caspase activation and apoptosis in injured neurons, and may thus represent a novel target for therapeutic treatment in neurodegenerative disorders.
Alternate Names: NALP5, NLR family pyrin domain containing 5, NLRP5, MATER, PYRIN-containing APAF1-like protein 8, PYPAF8, CLR19.8, PAN11
Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500
Accession No.: NP_703148
Antigen: KLH-conjugated synthetic peptide encompassing a sequence within human NALP5.
Format: Each vial contains 0.1 ml IgG in PBS pH 7.4 with 0.02% sodium azide. Antibody was purified by immunogen affinity chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
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