NALP6 polyclonal, anti-human
€484.00
In stock
SKU
254346
Protein Family: Enzymes
Pathway and Disease: Signaling Molecules and Interaction
Description:
NALP proteins include the apoptosis regulator APAF1 (apoptotic protease activating factor 1) and mammalian NOD-LRR proteins and are thought to be involved in inflammation and reproduction. NALP6, also known as PYPAF5, is highly expressed in granulocytes and T cells and co-localizes with the PYRIN-CARD protein ASC. Co-expression of NALP6 with ASC results in a synergistic activation of NF-kappaB and activated caspase-1-dependent cytokine processing, suggesting that NALP6 functions in immune cells to coordinate the transduction of pro-inflammatory signals.
Alternate Names: NALP6, NLR family pyrin domain containing 6, NLRP6, PYRIN-containing APAF1-like protein 5, PYPAF5, CLR11.4, PAN3
Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500
Accession No.: NP_612202
Antigen: KLH-conjugated synthetic peptide encompassing a sequence within human NALP6.
Format: Each vial contains 0.1 ml IgG in PBS pH 7.4 with 0.02% sodium azide. Antibody was purified by immunogen affinity chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Pathway and Disease: Signaling Molecules and Interaction
Description:
NALP proteins include the apoptosis regulator APAF1 (apoptotic protease activating factor 1) and mammalian NOD-LRR proteins and are thought to be involved in inflammation and reproduction. NALP6, also known as PYPAF5, is highly expressed in granulocytes and T cells and co-localizes with the PYRIN-CARD protein ASC. Co-expression of NALP6 with ASC results in a synergistic activation of NF-kappaB and activated caspase-1-dependent cytokine processing, suggesting that NALP6 functions in immune cells to coordinate the transduction of pro-inflammatory signals.
Alternate Names: NALP6, NLR family pyrin domain containing 6, NLRP6, PYRIN-containing APAF1-like protein 5, PYPAF5, CLR11.4, PAN3
Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500
Accession No.: NP_612202
Antigen: KLH-conjugated synthetic peptide encompassing a sequence within human NALP6.
Format: Each vial contains 0.1 ml IgG in PBS pH 7.4 with 0.02% sodium azide. Antibody was purified by immunogen affinity chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
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