NAMPT Polyclonal Antibody

Background:
Nicotinamide phosphoribosyltransferase(NAMPT) has two usual synonyms termed Visfatin and PBEF. Its primary role is to catalyze the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD, which is the rate limiting component in the mammalian NAD biosynthesis pathway. NAMPT is localized in cytoplasm and expressed in large amounts in bone marrow, liver tissue, and muscle tissues. NAMPT inhibits neutrophil apoptosis in experimental inflammation and clinical sepsis. NAMPT levels are altered in plasma of patients with type 2 diabetes mellitus (T2DM), and it is now evidenced that NAMPT may plays a role in lipid metabolism.

Research Area: Cancer, Cardiovascular, Metabolism, Immunology, Neuroscience, Signaling transduction

Synonyms:
1110035O14Rik, AI314458, AI480535, DKFZP666B131, EC 2.4.2.12, MGC117256, NAmPRTase, Nampt, NAMPT, Nicotinamide phosphoribosyltransferase, PBEF 1, PBEF, PBEF1, Pre B cell colony enhancing factor 1, Pre B cell colony enhancing factor, Pre B cell enhancing factor, Pre-B cell-enhancing factor, Pre-B-cell colony-enhancing factor 1, VF, Visfatin

Immunogen: Recombinant Human Nicotinamide phosphoribosyltransferase protein

Swissprot: P43490
Gene Accession: BC072439

Calculated MW: 56 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide and 50% glycerol pH 7.4.

Concentration: 2 mg/mL
Dilution: WB 1:500-1:1000, IHC 1:50-1:100

Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Citation(s):
https://www.sciencedirect.com/science/article/pii/S006512811830223X