NANOG (clone 1E6C4), anti-human
€478.00
In stock
SKU
252838
Protein Family: Cellular Antigens, Transcription Factors
Pathway and Disease: Cell Growth and Death
Description:
Nanog (Homeobox protein NANOG) is a transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Nanog imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Nanog blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes.
Alternate Names: Nanog, Homeobox protein NANOG, Homeobox transcription factor Nanog, hNanog, ES cell-associated protein 4, Early embryo specific expression NK-type homeobox protein, Ecat4, Enk
Application Notes: WB: 1:500-1:2000; IF: 1:200-1:1000
Accession No.: Q80Z64
Antigen: Purified recombinant fragment of NANOG (aa20-166) expressed in E. coli.
Format: Each vial contains 0.1 ml ascitic fluid with 0.03% sodium azide.
Storage:
Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment.
Pathway and Disease: Cell Growth and Death
Description:
Nanog (Homeobox protein NANOG) is a transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Nanog imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Nanog blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes.
Alternate Names: Nanog, Homeobox protein NANOG, Homeobox transcription factor Nanog, hNanog, ES cell-associated protein 4, Early embryo specific expression NK-type homeobox protein, Ecat4, Enk
Application Notes: WB: 1:500-1:2000; IF: 1:200-1:1000
Accession No.: Q80Z64
Antigen: Purified recombinant fragment of NANOG (aa20-166) expressed in E. coli.
Format: Each vial contains 0.1 ml ascitic fluid with 0.03% sodium azide.
Storage:
Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment.
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