NANOG monoclonal, anti-human
€0.00
In stock
SKU
AC-AM1486b
Catalog Number: AC-AM1486b
Size: 80 µl, 400 µl
Isotype: mouse IgG1,k
Clone Name: 60CT77.1.1
Applications: WB, IHC-P
Datasheet
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Size: 80 µl, 400 µl
Isotype: mouse IgG1,k
Clone Name: 60CT77.1.1
Applications: WB, IHC-P
Datasheet
Request Information
Background:
Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes (By similarity). Acts as a transcriptional activator or repressor (By similarity). Binds optimally to the DNA consensus sequence 5'-TAAT[GT][GT]-3' or 5'-[CG][GA][CG]C[GC]ATTAN[GC]-3' (By similarity). When overexpressed, promotes cells to enter into S phase and proliferation (By similarity).
Other Names:
Homeobox protein NANOG, Homeobox transcription factor Nanog, hNanog, NANOG
Target/Specificity:
This NANOG monoclonal antibody is generated from mouse immunized with NANOG recombinant protein.
Antigen Type: Recombinant Protein
Gene Name: NANOG
Gene ID: 79923
Primary Accession: Q9H9S0
NCBI Accession: NP_079141.2
Other Accession: NP_079141.2;XP_002344676.1
Format: Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.
Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes (By similarity). Acts as a transcriptional activator or repressor (By similarity). Binds optimally to the DNA consensus sequence 5'-TAAT[GT][GT]-3' or 5'-[CG][GA][CG]C[GC]ATTAN[GC]-3' (By similarity). When overexpressed, promotes cells to enter into S phase and proliferation (By similarity).
Other Names:
Homeobox protein NANOG, Homeobox transcription factor Nanog, hNanog, NANOG
Target/Specificity:
This NANOG monoclonal antibody is generated from mouse immunized with NANOG recombinant protein.
Antigen Type: Recombinant Protein
Gene Name: NANOG
Gene ID: 79923
Primary Accession: Q9H9S0
NCBI Accession: NP_079141.2
Other Accession: NP_079141.2;XP_002344676.1
Format: Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.
| Is Featured? | No |
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