NANOG polyclonal (N-term), anti-human
€0.00
In stock
SKU
AC-AP1486A
Catalog Number: AC-AP1486A
Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB13815
Applications: IF, FC, IHC-P, WB
Datasheet
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Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB13815
Applications: IF, FC, IHC-P, WB
Datasheet
Request Information
Background:
NANOG is a transcription regulator involved in inner cell mass and embryonic stem (ES) cell proliferation and self-renewal. It imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. This protein blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes. NANOG acts as a transcriptional activator or repressor. It binds optimally to the DNA consensus sequence 5'-[CG][GA][CG]C[GC]ATTAN[GC]-3'. When overexpressed, this protein promotes cells to enter into S phase and proliferation.
Other Names:
Homeobox protein NANOG, Homeobox transcription factor Nanog, hNanog, NANOG
Target/Specificity:
This NANOG antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 15-49 amino acids from the N-terminal region of human NANOG.
Antigen Region:
15-49
Antigen Type: Synthetic Peptide
Gene Name: NANOG
Gene ID: 79923
Primary Accession: Q9H9S0
NCBI Accession: NP_079141.2
Other Accession: Q6NSW7; Q5TM84
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
NANOG is a transcription regulator involved in inner cell mass and embryonic stem (ES) cell proliferation and self-renewal. It imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. This protein blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes. NANOG acts as a transcriptional activator or repressor. It binds optimally to the DNA consensus sequence 5'-[CG][GA][CG]C[GC]ATTAN[GC]-3'. When overexpressed, this protein promotes cells to enter into S phase and proliferation.
Other Names:
Homeobox protein NANOG, Homeobox transcription factor Nanog, hNanog, NANOG
Target/Specificity:
This NANOG antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 15-49 amino acids from the N-terminal region of human NANOG.
Antigen Region:
15-49
Antigen Type: Synthetic Peptide
Gene Name: NANOG
Gene ID: 79923
Primary Accession: Q9H9S0
NCBI Accession: NP_079141.2
Other Accession: Q6NSW7; Q5TM84
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
| Is Featured? | No |
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