Nanog (Rodent) polyclonal, anti-mouse, rat

Protein Family: Cellular Antigens, Transcription Factors

Pathway and Disease: Cell Growth and Death

Description:
Nanog (Homeobox protein NANOG) is a transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Nanog imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Nanog blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes.

Alternate Names: Nanog, Homeobox protein NANOG, Homeobox transcription factor Nanog, hNanog, ES cell-associated protein 4, Early embryo specific expression NK-type homeobox protein, Ecat4, Enk

Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500

Accession No.: Q80Z64

Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of mouse nanog.

Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.