NARF Antibody (Center) Blocking Peptide
€363.00
In stock
SKU
AC-BP17343c
Background:
Several proteins have been found to be prenylated andmethylated at their carboxyl-terminal ends. Prenylation wasinitially believed to be important only for membrane attachment.However, another role for prenylation appears to be its importancein protein-protein interactions. The only nuclear proteins known tobe prenylated in mammalian cells are prelamin A- and B-type lamins.Prelamin A is farnesylated and carboxymethylated on the cysteineresidue of a carboxyl-terminal CaaX motif. Thispost-translationally modified cysteine residue is removed fromprelamin A when it is endoproteolytically processed into maturelamin A. The protein encoded by this gene binds to the prenylatedprelamin A carboxyl-terminal tail domain. It may be a component ofa prelamin A endoprotease complex. The encoded protein is locatedin the nucleus, where it partially colocalizes with the nuclearlamina. It shares limited sequence similarity with iron-onlybacterial hydrogenases. Alternatively spliced transcript variantsencoding different isoforms have been identified for this gene,including one with a novel exon that is generated by RNA editing.
Other Names:
Nuclear prelamin A recognition factor, Iron-only hydrogenase-like protein 2, IOP2, NARF
Gene Name: NARF
Gene ID: 26502
Primary Accession: Q9UHQ1
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Several proteins have been found to be prenylated andmethylated at their carboxyl-terminal ends. Prenylation wasinitially believed to be important only for membrane attachment.However, another role for prenylation appears to be its importancein protein-protein interactions. The only nuclear proteins known tobe prenylated in mammalian cells are prelamin A- and B-type lamins.Prelamin A is farnesylated and carboxymethylated on the cysteineresidue of a carboxyl-terminal CaaX motif. Thispost-translationally modified cysteine residue is removed fromprelamin A when it is endoproteolytically processed into maturelamin A. The protein encoded by this gene binds to the prenylatedprelamin A carboxyl-terminal tail domain. It may be a component ofa prelamin A endoprotease complex. The encoded protein is locatedin the nucleus, where it partially colocalizes with the nuclearlamina. It shares limited sequence similarity with iron-onlybacterial hydrogenases. Alternatively spliced transcript variantsencoding different isoforms have been identified for this gene,including one with a novel exon that is generated by RNA editing.
Other Names:
Nuclear prelamin A recognition factor, Iron-only hydrogenase-like protein 2, IOP2, NARF
Gene Name: NARF
Gene ID: 26502
Primary Accession: Q9UHQ1
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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