NARF antibody (clone 7D9), anti-human
€435.00
In stock
SKU
AC-AT2972a
Catalog Number: AC-AT2972a
Size: 200 µl
Isotype: mouse IgM Kappa
Applications: WB
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Size: 200 µl
Isotype: mouse IgM Kappa
Applications: WB
Request Information AC-AT2972a">Request Information
Background:
Several proteins have been found to be prenylated and methylated at their carboxyl-terminal ends. Prenylation was initially believed to be important only for membrane attachment. However, another role for prenylation appears to be its importance in protein-protein interactions. The only nuclear proteins known to be prenylated in mammalian cells are prelamin A- and B-type lamins. Prelamin A is farnesylated and carboxymethylated on the cysteine residue of a carboxyl-terminal CaaX motif. This post-translationally modified cysteine residue is removed from prelamin A when it is endoproteolytically processed into mature lamin A. The protein encoded by this gene binds to the prenylated prelamin A carboxyl-terminal tail domain. It may be a component of a prelamin A endoprotease complex. The encoded protein is located in the nucleus, where it partially colocalizes with the nuclear lamina. It shares limited sequence similarity with iron-only bacterial hydrogenases. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene, including one with a novel exon that is generated by RNA editing. [provided by RefSeq]
Other Names:
Nuclear prelamin A recognition factor, Iron-only hydrogenase-like protein 2, IOP2, NARF
Antigen Type:
Recombinant Protein
Gene Name: NARF
Gene ID: 26502
NCBI Accession: NP_001033707.1;NP_001077077.1;NP_036468.1;NP_114174.1
Primary Accession: Q9UHQ1
Other Accession: NM_031968
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
Several proteins have been found to be prenylated and methylated at their carboxyl-terminal ends. Prenylation was initially believed to be important only for membrane attachment. However, another role for prenylation appears to be its importance in protein-protein interactions. The only nuclear proteins known to be prenylated in mammalian cells are prelamin A- and B-type lamins. Prelamin A is farnesylated and carboxymethylated on the cysteine residue of a carboxyl-terminal CaaX motif. This post-translationally modified cysteine residue is removed from prelamin A when it is endoproteolytically processed into mature lamin A. The protein encoded by this gene binds to the prenylated prelamin A carboxyl-terminal tail domain. It may be a component of a prelamin A endoprotease complex. The encoded protein is located in the nucleus, where it partially colocalizes with the nuclear lamina. It shares limited sequence similarity with iron-only bacterial hydrogenases. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene, including one with a novel exon that is generated by RNA editing. [provided by RefSeq]
Other Names:
Nuclear prelamin A recognition factor, Iron-only hydrogenase-like protein 2, IOP2, NARF
Antigen Type:
Recombinant Protein
Gene Name: NARF
Gene ID: 26502
NCBI Accession: NP_001033707.1;NP_001077077.1;NP_036468.1;NP_114174.1
Primary Accession: Q9UHQ1
Other Accession: NM_031968
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
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