NaV1.8 polyclonal, anti-mouse, rat

Background:
Tetrodotoxin-resistant channel that mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. Plays a role in neuropathic pain mechanisms.

Alternative Name:
PN3, Scn10a, Sns, hPN3, mPN3, Peripheral nerve sodium channel 3, Pn3 (gene name), PN3, SCN10A, SCNAA, Sensory neuron sodium channel, Sns (gene name), SNS, Sodium channel protein type 10 subunit alpha, Sodium channel protein type X alpha subunit, Sodium channel protein type X subunit alpha, Voltage-gated sodium channel alpha subunit Nav1.8, Voltage-gated sodium channel subunit alpha Nav1.8,

Application Dilution:
WB:1:100-1:500
IHC:1:50-1:200

Specificity: NaV1.8 polyclonal antibody detects endogenous levels of NaV1.8 protein.

Immunogen:
Recombinant protein

MW: 220 kDa

Swiss-Prot: Q6QIY3(Mouse) Q62968(Rat)

Purification & Purity:
ProA affinity purified

Format:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Storage:
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

For research use only, not for use in diagnostic procedure.