NBN polyclonal, anti-human, mouse, rat

Background:
Mutations in this gene are associated with Nijmegen breakage syndrome, an autosomal recessive chromosomal instability syndrome characterized by microcephaly, growth retardation, immunodeficiency, and cancer predisposition. The encoded protein is a member of the MRE11/RAD50 double-strand break repair complex which consists of 5 proteins. This gene product is thought to be involved in DNA double-strand break repair and DNA damage-induced checkpoint activation.

Synonyms: AT-V1, AT-V2, ATV, NBS, NBS1, P95

Cellular Location: Chromosome Nucleus PML body telomere

Immunogen:
A synthetic peptide of human NBN

Gene Symbol: NBN

Gene ID: 4683

Swiss prot: O60934

Calculated MW: 85kDa

Recommended dilution:
WB 1:500-2000, IF 1:50-200,

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Storage:
Store at -20℃. Avoid freeze / thaw cycles.