NBN Polyclonal Antibody

Background:
Mutations in this gene are associated with Nijmegen breakage syndrome, an autosomal recessive chromosomal instability syndrome characterized by microcephaly, growth retardation, immunodeficiency, and cancer predisposition. The encoded protein is a member of the MRE11/RAD50 double-strand break repair complex which consists of 5 proteins. This gene product is thought to be involved in DNA double-strand break repair and DNA damage-induced checkpoint activation.

Research Area: Cancer, Epigenetics and Nuclear Signaling

Synonyms:
NBN, AT-V1, AT-V2, ATV, NBS, NBS1, P95, nibrin

Immunogen: A synthetic peptide of human NBN

Swissprot: O60934
Gene ID: 4683

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Concentration: 1 mg/mL
Dilution: IF 1:50-1:200

Storage:
Store at -20°C. Avoid freeze / thaw cycles.