NBR1 (clone 7C3) mouse monoclonal, anti-human, mouse, rat

Backgroud: The protein encoded by this gene was originally identified as an ovarian tumor antigen monitored in ovarian cancer. The encoded protein contains a B-box/coiled-coil motif, which is present in many genes with transformation potential. It functions as a specific autophagy receptor for the selective autophagic degradation of peroxisomes by forming intracellular inclusions with ubiquitylated autophagic substrates. This gene is located on a region of chromosome 17q21.1 that is in close proximity to the BRCA1 tumor suppressor gene. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2014],caution:Was originally (PubMed:8069304) thought to be the ovarian carcinoma antigen CA125.,domain:The OPR domain mediates interaction with SQSTM1.,similarity:Contains 1 OPR domain.,similarity:Contains 1 UBA domain.,similarity:Contains 1 ZZ-type zinc finger.,subunit:Homooligomer and heterooligomer. Interacts with SQSTM1, titin/TTN and RNF29.,

Synonyms: Next to BRCA1 gene 1 protein (Cell migration-inducing gene 19 protein) (Membrane component chromosome 17 surface marker 2) (Neighbor of BRCA1 gene 1 protein) (Protein 1A1-3B)

Gene Name: NBR1 1A13B KIAA0049 M17S2 MIG19

Gene ID: 4077

SwissProt ID: Q14596

Purification: Affinity purification

Storage: Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.