NBR1 Monoclonal Antibody

Background:
The protein encoded by this gene was originally identified as an ovarian tumor antigen monitored in ovarian cancer. The encoded protein contains a B-box/coiled-coil motif, which is present in many genes with transformation potential. It functions as a specific autophagy receptor for the selective autophagic degradation of peroxisomes by forming intracellular inclusions with ubiquitylated autophagic substrates. This gene is located on a region of chromosome 17q21.1 that is in close proximity to the BRCA1 tumor suppressor gene. Alternative splicing of this gene results in multiple transcript variants.NBR1 (NBR1, Autophagy Cargo Receptor) is a Protein Coding gene. Diseases associated with NBR1 include Inclusion Body Myositis and Synucleinopathy. Among its related pathways are Mitophagy - animal. GO annotations related to this gene include ubiquitin binding and mitogen-activated protein kinase binding.

Research Area: Cancer, Cell Biology

Synonyms:
1A1 3B, 1A13B, B box protein, Cell migration-inducing gene 19 protein, KIAA0049, M17S2, Membrane component chromosome 17 surface marker 2, Membrane component, chromosome 17, surface marker 2 (ovarian carcinoma antigen CA125), MIG 19, MIG19, Migration inducing protein 19, NBR 1, Nbr1, NBR1, autophagy cargo receptor, NBR1, Neighbor of BRCA1 gene 1, Neighbor of BRCA1 gene 1 protein, Next to BRCA1 gene 1 protein, Ovarian carcinoma antigen CA125, Protein 1A1-3B

Immunogen: Recombinant Protein of NBR1

Swissprot: Q14596

Purification Method: Protein A purification

Buffer: PBS with 0.02% sodium azide and 50% glycerol pH 7.4.

Concentration: 1 mg/mL
Dilution: IHC 1:50-300, IF 1:50-1:200

Storage:
Store at -20°C. Avoid freeze / thaw cycles.