CD56 (NCAM1) polyclonal, anti-human, mouse, rat
€305.00
In stock
SKU
BS61516
Background:
NCAM (neural cell adhesion molecule, CD56) is an adhesion glycoprotein with five extracellular immunoglobulin-like domains followed by two fibronectin type III repeats. Structural diversity is introduced by alternative splicing resulting in different cytoplasmic domains . NCAM mediates neuronal attachment, neurite extension and cell-cell interactions through homo and heterophilic interactions. PSA (polysialic acid) post-translationally modifies NCAM and increases the metastatic potential of small cell lung carcinoma, Wilms+ tumor, neuroblastoma and rhabdomyosarcoma . CD56 and CD16 are commonly used to identify NK cells although some cells with the T cell markers CD3 and CD4 also express CD56 .
Alternative Name:
Neural cell adhesion molecule 1, N-CAM-1, NCAM-1, CD56
Application Dilution: WB: 1:500~1:1000
Specificity: NCAM1 polyclonal antibody detects endogenous levels of NCAM1 protein.
Immunogen:
Synthetic peptide, corresponding to amino acids 262-306 of Human NCAM1.
MW: ~ 120-160 kDa
Swis Prot.: P13591
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE)
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.3.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
NCAM (neural cell adhesion molecule, CD56) is an adhesion glycoprotein with five extracellular immunoglobulin-like domains followed by two fibronectin type III repeats. Structural diversity is introduced by alternative splicing resulting in different cytoplasmic domains . NCAM mediates neuronal attachment, neurite extension and cell-cell interactions through homo and heterophilic interactions. PSA (polysialic acid) post-translationally modifies NCAM and increases the metastatic potential of small cell lung carcinoma, Wilms+ tumor, neuroblastoma and rhabdomyosarcoma . CD56 and CD16 are commonly used to identify NK cells although some cells with the T cell markers CD3 and CD4 also express CD56 .
Alternative Name:
Neural cell adhesion molecule 1, N-CAM-1, NCAM-1, CD56
Application Dilution: WB: 1:500~1:1000
Specificity: NCAM1 polyclonal antibody detects endogenous levels of NCAM1 protein.
Immunogen:
Synthetic peptide, corresponding to amino acids 262-306 of Human NCAM1.
MW: ~ 120-160 kDa
Swis Prot.: P13591
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE)
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.3.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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