NCAPH2 polyclonal, anti-human

Background:
Regulatory subunit of the condensin-2 complex, a complex that seems to provide chromosomes with an additional level of organization and rigidity and in establishing mitotic chromosome architecture (PubMed:14532007). May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Required for decatenation of chromatin bridges at anaphase. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (By similarity). Seems to have lineage-specific role in T-cell development (PubMed:14532007).

Synonyms: 384D8 2, 384D8_6, CAP H2, CAPH2, Condensin 2 complex subunit H2, hCAP H2, Kleisin beta, NCAPH2

Cellular Location: Nucleus

Immunogen:
Recombinant protein of human NCAPH2

Gene Symbol: NCAPH2

Gene ID: 29781

Swiss prot: Q6IBW4

Calculated MW: 33/68kDa

Recommended dilution:
WB 1:2000-5000

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.

Storage:
Store at -20°C. Avoid freeze / thaw cycles.