NCF4 antibody (clone 3C10), anti-human
€435.00
In stock
SKU
AC-AT2979a
Catalog Number: AC-AT2979a
Size: 100 µg
Isotype: mouse IgG2a Kappa
Applications: E
Request Information AC-AT2979a">Request Information
Size: 100 µg
Isotype: mouse IgG2a Kappa
Applications: E
Request Information AC-AT2979a">Request Information
Background:
The protein encoded by this gene is a cytosolic regulatory component of the superoxide-producing phagocyte NADPH-oxidase, a multicomponent enzyme system important for host defense. This protein is preferentially expressed in cells of myeloid lineage. It interacts primarily with neutrophil cytosolic factor 2 (NCF2/p67-phox) to form a complex with neutrophil cytosolic factor 1 (NCF1/p47-phox), which further interacts with the small G protein RAC1 and translocates to the membrane upon cell stimulation. This complex then activates flavocytochrome b, the membrane-integrated catalytic core of the enzyme system. The PX domain of this protein can bind phospholipid products of the PI(3) kinase, which suggests its role in PI(3) kinase-mediated signaling events. The phosphorylation of this protein was found to negatively regulate the enzyme activity. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
Other Names:
Neutrophil cytosol factor 4, NCF-4, Neutrophil NADPH oxidase factor 4, SH3 and PX domain-containing protein 4, p40-phox, p40phox, NCF4, SH3PXD4
Antigen Type:
Recombinant Protein
Gene Name: NCF4
Gene ID: 4689
NCBI Accession: NP_000622.2;NP_038202.2
Primary Accession: Q15080
Other Accession: BC002798
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
The protein encoded by this gene is a cytosolic regulatory component of the superoxide-producing phagocyte NADPH-oxidase, a multicomponent enzyme system important for host defense. This protein is preferentially expressed in cells of myeloid lineage. It interacts primarily with neutrophil cytosolic factor 2 (NCF2/p67-phox) to form a complex with neutrophil cytosolic factor 1 (NCF1/p47-phox), which further interacts with the small G protein RAC1 and translocates to the membrane upon cell stimulation. This complex then activates flavocytochrome b, the membrane-integrated catalytic core of the enzyme system. The PX domain of this protein can bind phospholipid products of the PI(3) kinase, which suggests its role in PI(3) kinase-mediated signaling events. The phosphorylation of this protein was found to negatively regulate the enzyme activity. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
Other Names:
Neutrophil cytosol factor 4, NCF-4, Neutrophil NADPH oxidase factor 4, SH3 and PX domain-containing protein 4, p40-phox, p40phox, NCF4, SH3PXD4
Antigen Type:
Recombinant Protein
Gene Name: NCF4
Gene ID: 4689
NCBI Accession: NP_000622.2;NP_038202.2
Primary Accession: Q15080
Other Accession: BC002798
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
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