NCK1 polyclonal, anti-human, mouse, rat
€388.00
In stock
SKU
BS6103
Background:
Adapter protein which associates with tyrosine-phosphorylated growth factor receptors, such as R and PDGFRB, or their cellular substrates. Maintains low EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in the DNA damage response, not in the detection of the damage by ATM/ATR, but for efficient activation of downstream effectors, such as that of CHEK2. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling.
Alternative Name:
Cytoplasmic protein NCK1, Melanoma Nck protein, MGC12668, NCK 1, Nck adaptor protein 1, NCK alpha, NCK, NCK tyrosine kinase, Nck-1, NCK1, NCK1, NCKalpha, Non catalytic region of tyrosine kinase, SH2/SH3 adaptor protein NCK alpha, SH2/SH3 adaptor protein NCK-alpha, SH2/SH3 adaptor protein NCKalpha,
Application Dilution: WB: 1:500~1:2000, IF: 1:50~1:200
Specificity: NCK1 polyclonal antibody detects endogenous levels of NCK1 protein.
Immunogen:
Recombinant full length Human NCK1.
MW: ~ 47 kDa
Swis Prot.: P16333
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
Adapter protein which associates with tyrosine-phosphorylated growth factor receptors, such as R and PDGFRB, or their cellular substrates. Maintains low EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in the DNA damage response, not in the detection of the damage by ATM/ATR, but for efficient activation of downstream effectors, such as that of CHEK2. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling.
Alternative Name:
Cytoplasmic protein NCK1, Melanoma Nck protein, MGC12668, NCK 1, Nck adaptor protein 1, NCK alpha, NCK, NCK tyrosine kinase, Nck-1, NCK1, NCK1, NCKalpha, Non catalytic region of tyrosine kinase, SH2/SH3 adaptor protein NCK alpha, SH2/SH3 adaptor protein NCK-alpha, SH2/SH3 adaptor protein NCKalpha,
Application Dilution: WB: 1:500~1:2000, IF: 1:50~1:200
Specificity: NCK1 polyclonal antibody detects endogenous levels of NCK1 protein.
Immunogen:
Recombinant full length Human NCK1.
MW: ~ 47 kDa
Swis Prot.: P16333
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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