NCOA2 polyclonal (Center), anti-human
€0.00
In stock
SKU
AC-AP21855c
Catalog Number: AC-AP21855c
Size: 50 µl, 200 µl
Isotype: Rabbit IgG
Clone Name: RB54073
Applications: WB
Datasheet
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Size: 50 µl, 200 µl
Isotype: Rabbit IgG
Clone Name: RB54073
Applications: WB
Datasheet
Request Information
Background:
Transcriptional coactivator for steroid receptors and nuclear receptors. Coactivator of the steroid binding domain (AF- 2) but not of the modulating N-terminal domain (AF-1). Required with NCOA1 to control energy balance between white and brown adipose tissues. Critical regulator of glucose metabolism regulation, acts as RORA coactivator to specifically modulate G6PC expression. Involved in the positive regulation of the transcriptional activity of the glucocorticoid receptor NR3C1 by sumoylation enhancer RWDD3. Positively regulates the circadian clock by acting as a transcriptional coactivator for the CLOCK- ARNTL/BMAL1 heterodimer (By similarity).
Other Names:
Nuclear receptor coactivator 2, NCoA-2, Class E basic helix-loop-helix protein 75, bHLHe75, Transcriptional intermediary factor 2, hTIF2, NCOA2, BHLHE75, SRC2, TIF2
Target/Specificity:
This NCOA2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 706-739 amino acids from the Central region of human NCOA2.
Gene Name: NCOA2
Gene ID: 10499
Primary Accession: Q15596
Other Accession: Q9W705;B5DE09
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Transcriptional coactivator for steroid receptors and nuclear receptors. Coactivator of the steroid binding domain (AF- 2) but not of the modulating N-terminal domain (AF-1). Required with NCOA1 to control energy balance between white and brown adipose tissues. Critical regulator of glucose metabolism regulation, acts as RORA coactivator to specifically modulate G6PC expression. Involved in the positive regulation of the transcriptional activity of the glucocorticoid receptor NR3C1 by sumoylation enhancer RWDD3. Positively regulates the circadian clock by acting as a transcriptional coactivator for the CLOCK- ARNTL/BMAL1 heterodimer (By similarity).
Other Names:
Nuclear receptor coactivator 2, NCoA-2, Class E basic helix-loop-helix protein 75, bHLHe75, Transcriptional intermediary factor 2, hTIF2, NCOA2, BHLHE75, SRC2, TIF2
Target/Specificity:
This NCOA2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 706-739 amino acids from the Central region of human NCOA2.
Gene Name: NCOA2
Gene ID: 10499
Primary Accession: Q15596
Other Accession: Q9W705;B5DE09
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
| Is Featured? | No |
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