Cytokeratin 17 polyclonal, anti-human, mouse, rat
€470.00
In stock
SKU
AC-AP69448
Catalog Number: AC-AP51379
Size: 100 µl
Host: Rabbit
Applications: WB, IP, IHC-P, E
Datasheet
Request Information
Size: 100 µl
Host: Rabbit
Applications: WB, IP, IHC-P, E
Datasheet
Request Information
Background:
Type I keratin involved in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair (By similarity). Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state (By similarity). Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway (By similarity). Involved in tissue repair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial "stem cells". Acts as a promoter of epithelial proliferation by acting a regulator of immune response in skin: promotes Th1/Th17-dominated immune environment contributing to the development of basaloid skin tumors (By similarity). May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation.
Other Names:
KRT17; Keratin; type I cytoskeletal 17; 39.1; Cytokeratin-17; CK-17; Keratin-17; K17
Antigen Type: synthetic peptide
Antigen Type: KRT17
Gene ID: 3872
Primary Accession: Q04695
Type I keratin involved in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair (By similarity). Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state (By similarity). Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway (By similarity). Involved in tissue repair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial "stem cells". Acts as a promoter of epithelial proliferation by acting a regulator of immune response in skin: promotes Th1/Th17-dominated immune environment contributing to the development of basaloid skin tumors (By similarity). May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation.
Other Names:
KRT17; Keratin; type I cytoskeletal 17; 39.1; Cytokeratin-17; CK-17; Keratin-17; K17
Antigen Type: synthetic peptide
Antigen Type: KRT17
Gene ID: 3872
Primary Accession: Q04695
| Is Featured? | No |
|---|
Write Your Own Review