NCR2 Polyclonal Antibody

Background:
Natural cytotoxicity triggering receptor 2is aproteinthat in humans is encoded by theNCR2gene. NCR2 has also been designated asCD336(cluster of differentiation336). NKp44 is a natural cytotoxicity receptor that is is expressed on IL-2-activated human NK cells and may contribute to the increased efficiency of NK cells to mediate tumor cell lysis. NKp44 is composed of one Ig-like extracellular domain, a transmembrane segment, and a cytoplasmic domain. Prolactin up-regulates and cortisol down-regulates the surface expression of NKp44 at the transcriptional level. A cellular ligand for NKp44 (NKp44L) is expressed during HIV-1 infection and is correlated with the progression of CD4+ T cell depletion and an increase of viral load.

Research Area: Cancer, Immunology, Signal transduction

Synonyms:
Activating NK receptor NKp44, CD336, CD336 antigen, dJ149M18.1, LY95, Lymphocyte antigen 95 (activating NK receptor, NK p44), Lymphocyte antigen 95 homolog (activating NK receptor, NK p44), Lymphocyte antigen 95 homolog, Lymphocyte antigen 95, mouse, homolog of, Natural cytotoxicity triggering receptor 2, Natural killer cell p44 related protein, Natural killer cell p44-related protein, NCR2, NCTR2, NK cell activating receptor (NKp44), NK cell activating receptor, NK cell-activating receptor, NK p44, NK-p44, NKp44

Immunogen: Synthetic peptide of human NCR2

Swissprot: O95944
Gene Accession: NP_001186438

Purification Method: Affinity purification

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Concentration: 0.7 mg/mL
Dilution: IHC 1:50-1:200

Storage:
Store at -20°C. Avoid freeze / thaw cycles.