NCX1 Polyclonal Antibody

Background:
solute carrier family 8 member A1(SLC8A1) Homo sapiens In cardiac myocytes, Ca(2+) concentrations alternate between high levels during contraction and low levels during relaxation. The increase in Ca(2+) concentration during contraction is primarily due to release of Ca(2+) from intracellular stores. However, some Ca(2+) also enters the cell through the sarcolemma (plasma membrane). During relaxation, Ca(2+) is sequestered within the intracellular stores. To prevent overloading of intracellular stores, the Ca(2+) that entered across the sarcolemma must be extruded from the cell. The Na(+)-Ca(2+) exchanger is the primary mechanism by which the Ca(2+) is extruded from the cell during relaxation. In the heart, the exchanger may play a key role in digitalis action. The exchanger is the dominant mechanism in returning the cardiac myocyte to its resting state following excitation.[supplied by OMIM, Apr 2004],

Alternative Names:
SLC8A1, CNC, NCX1, Sodium/calcium exchanger 1, Na(+)/Ca(2+)-exchange protein 1

Immunogen: Synthesized peptide derived from NCX1 . at AA range: 270-350

Isotype: Rabbit

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml

Observed band: 108

GeneID: SLC8A1

Storage: -20°C/1 year

NOTE: For Research Use Only