NDE1 Antibody (N-term) Blocking Peptide
€363.00
In stock
SKU
AC-BP8800a
Background:
NDE1 is required for centrosome duplication. It is essential for the development of the cerebral cortex. It may regulate the production of neurons by controlling the orientation of the mitotic spindle during division of cortical neuronal progenitors of the proliferative ventricular zone of the brain. Orientation of the division plane perpendicular to the layers of the cortex gives rise to two proliferative neuronal progenitors whereas parallel orientation of the division plane yields one proliferative neuronal progenitor and a post-mitotic neuron. A premature shift towards a neuronal fate within the progenitor population may result in an overall reduction in the final number of neurons and an increase in the number of neurons in the deeper layers of the cortex (By similarity). This protein is required for formation and function of the mitotic spindle.
Other Names:
Nuclear distribution protein nudE homolog 1, NudE, NDE1, NUDE
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP8800a was selected from the N-term region of human NDE1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: NDE1
Gene ID: 54820
Primary Accession: Q9NXR1
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
NDE1 is required for centrosome duplication. It is essential for the development of the cerebral cortex. It may regulate the production of neurons by controlling the orientation of the mitotic spindle during division of cortical neuronal progenitors of the proliferative ventricular zone of the brain. Orientation of the division plane perpendicular to the layers of the cortex gives rise to two proliferative neuronal progenitors whereas parallel orientation of the division plane yields one proliferative neuronal progenitor and a post-mitotic neuron. A premature shift towards a neuronal fate within the progenitor population may result in an overall reduction in the final number of neurons and an increase in the number of neurons in the deeper layers of the cortex (By similarity). This protein is required for formation and function of the mitotic spindle.
Other Names:
Nuclear distribution protein nudE homolog 1, NudE, NDE1, NUDE
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP8800a was selected from the N-term region of human NDE1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: NDE1
Gene ID: 54820
Primary Accession: Q9NXR1
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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