NDRG1 (Marker of Tumor Aggressiveness) (clone NDRG1/1383), anti-human
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In stock
SKU
AC-AH13081
Catalog Number: AC-AH13081
Size: 20 µg, 100 µg
Isotype: Mouse
Clone Name: NDRG1/1383
Applications: WB, IF, FC
Datasheet
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Size: 20 µg, 100 µg
Isotype: Mouse
Clone Name: NDRG1/1383
Applications: WB, IF, FC
Datasheet
Request Information
Background:
It recognizes a protein of 43kDa, which is identified as N-myc downstream-regulated gene 1 protein (NDRG1). The NDRG) family is comprised of four members, NDRG1, NDRG2, NDRG3 and NDRG4, which share 57-65% homology. The NDRG1 gene is ubiquitously expressed, but it is expressed most prominently in placental membranes and prostate, kidney, small intestine and ovary tissue. NDRG1 is a direct transcriptional target gene of p53 to mediated cell death and apoptosis. NDRG1 gene expression is induced by several compounds, including nickel, and produces a protein involved in stress responses, hormone responses, cell growth and differentiation. The reduced expression of NDRG1 has been found to be associated with tumor metastasis in a variety of tumors, including cancers of the breast, colon, prostate, oral cavity and oropharynx. Reportedly, overexpression of NDRG1 in hepatocellular carcinoma is an indicator of tumor aggressiveness.
Other Names:
GC4; cap43; cmt4d; Differentiation-related gene 1 protein; DRG-1; Hmsnl; Human mRNA for RTP complete cds; N-myc downstream-regulated gene 1 protein; NDRG1; Nickel-specific induction protein Cap43; Nmsl; Protein regulated by oxygen1; Proxy1; Reducin; Reducing agents and tunicamycin-responsive protein; Rit42; RTP; targ1; TDD5; Tunicamycin responsive protein
Antigen Type:
Recombinant protein
Gene Name: NDRG1
Gene ID: 10397
Primary Accession: Q92597
Other Accession: 372914
It recognizes a protein of 43kDa, which is identified as N-myc downstream-regulated gene 1 protein (NDRG1). The NDRG) family is comprised of four members, NDRG1, NDRG2, NDRG3 and NDRG4, which share 57-65% homology. The NDRG1 gene is ubiquitously expressed, but it is expressed most prominently in placental membranes and prostate, kidney, small intestine and ovary tissue. NDRG1 is a direct transcriptional target gene of p53 to mediated cell death and apoptosis. NDRG1 gene expression is induced by several compounds, including nickel, and produces a protein involved in stress responses, hormone responses, cell growth and differentiation. The reduced expression of NDRG1 has been found to be associated with tumor metastasis in a variety of tumors, including cancers of the breast, colon, prostate, oral cavity and oropharynx. Reportedly, overexpression of NDRG1 in hepatocellular carcinoma is an indicator of tumor aggressiveness.
Other Names:
GC4; cap43; cmt4d; Differentiation-related gene 1 protein; DRG-1; Hmsnl; Human mRNA for RTP complete cds; N-myc downstream-regulated gene 1 protein; NDRG1; Nickel-specific induction protein Cap43; Nmsl; Protein regulated by oxygen1; Proxy1; Reducin; Reducing agents and tunicamycin-responsive protein; Rit42; RTP; targ1; TDD5; Tunicamycin responsive protein
Antigen Type:
Recombinant protein
Gene Name: NDRG1
Gene ID: 10397
Primary Accession: Q92597
Other Accession: 372914
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