NDRG2 polyclonal, anti-human, mouse, rat

Background:
The N-myc downstream regulated gene (NDRG) family is comprised of four members, namely NDRG1, NDRG2, NDRG3 and NDRG4, all of which share 57-65% homology. NDRG2 (NDRG family member 2), also known as SYLD, is a 371 amino acid protein that localizes to both the cytoplasm and the perinuclear region in neurons. Expressed at high levels in heart, brain, dendritic cells, salivary gland and skeletal muscle and at lower levels in liver and kidney, NDRG2 is thought to be involved in dendritic and neuronal cell differentiation and outgrowth. Additionally, NDRG2 expression is downregulated in a variety of carcinomas, including liver cancer, pancreatic cancer and meningioma, suggesting a possible role for NDRG2 in tumor suppression. NDRG2 is found in brain lesions of Alzheimer Disease (AD)-affected patients and is thought to be associated with the progression of AD. Five isoforms of NDRG2 exist due to alternative splicing events.

Alternative Name:
NDRG2, KIAA1248, SYLD, Antidepressant related protein ADRG123, Cytoplasmic protein Ndr1, DKFZp781G1938, FLJ25522, KIAA1248, N myc downstream regulated gene 2, N myc downstream regulator 2, NDR1 related protein NDR2, NDRG 2, NDRG family member 2, NDRG1 related protein, NDRG2, NDRG2, Protein NDRG2, Protein Syld709613, SYLD, Syld709613 protein,

Application Dilution:
WB:1:500-1:1,000
ICC:1:50-1:200
IHC:1:50-1:100
FC:1:50-1:100

Specificity: NDRG2 polyclonal antibody detects endogenous levels of NDRG2 protein.

Immunogen:
Recombinant protein within human NDRG2 1-150 aa.

MW: 41 kDa

Swiss-Prot: Q9UN36(Human) Q9QYG0(Mouse) Q8VBU2(Rat)

Purification & Purity:
Protein affinity purified.

Format:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Storage:
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.

For research use only, not for use in diagnostic procedure.