NECTIN4 Polyclonal Antibody

Background:
This gene encodes a member of the nectin family. The encoded protein contains two immunoglobulin-like (Ig-like) C2-type domains and one Ig-like V-type domain. It is involved in cell adhesion through trans-homophilic and -heterophilic interactions. It is a single-pass type I membrane protein. The soluble form is produced by proteolytic cleavage at the cell surface by the metalloproteinase ADAM17/TACE. The secreted form is found in both breast tumor cell lines and breast tumor patients. Mutations in this gene are the cause of ectodermal dysplasia-syndactyly syndrome type 1, an autosomal recessive disorder. Alternatively spliced transcript variants have been found but the full-length nature of the variant has not been determined.

Research Area: Cell Biology

Synonyms:
DKFZp686K05193, EDSS1, Ig superfamily receptor LNIR, Nectin 4, Nectin-4, poliovirus receptor-related 4, Processed poliovirus receptor-related protein 4, PRR4, pvrl4, PVRL4

Immunogen: Recombinant protein of human PVRL4

Swissprot: Q96NY8
Gene Accession: BC010423

Calculated MW: 55 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Concentration: 0.9 mg/mL
Dilution: WB 1:500-1:2000, IHC 1:100-1:300

Storage:
Store at -20°C. Avoid freeze / thaw cycles.