NEDD4 polyclonal, anti-human
€388.00
In stock
SKU
BS70345
Background:
NEDD4 is a 221 amino acid, Golgi-associated protein which contains three transmembrane domains in its carboxy-terminus and two PY motifs in its amino-terminus. NEDD4 may play a role in Golgi structure and function. It binds the WW domains of a number of NEDD4 family members called HECT-type E3 ubiquitin ligases. NEDD4 is strongly expressed in surviving neurons around an injury site, which suggests that ubiquitination may be a possible survival strategy and that NEDD4 may act as a neuroprotective protein. It may also have an effect on the function of Itch, another E3 ubiquitin ligase. Expression of NEDD4 and its association with Itch may be promoted by T cell activation.
Alternative Name:
NEDD-4, NEDD4, KIAA0093, NEDD4-1, PIG53
Application Dilution: WB: 1:500 - 1:2000, IHC: 1:50 - 1:200
Specificity: NEDD4 polyclonal antibody detects endogenous levels of NEDD4 protein.
Immunogen:
Recombinant protein of human NEDD4.
MW: ~ 149 kDa
Swis Prot.: P46934
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
NEDD4 is a 221 amino acid, Golgi-associated protein which contains three transmembrane domains in its carboxy-terminus and two PY motifs in its amino-terminus. NEDD4 may play a role in Golgi structure and function. It binds the WW domains of a number of NEDD4 family members called HECT-type E3 ubiquitin ligases. NEDD4 is strongly expressed in surviving neurons around an injury site, which suggests that ubiquitination may be a possible survival strategy and that NEDD4 may act as a neuroprotective protein. It may also have an effect on the function of Itch, another E3 ubiquitin ligase. Expression of NEDD4 and its association with Itch may be promoted by T cell activation.
Alternative Name:
NEDD-4, NEDD4, KIAA0093, NEDD4-1, PIG53
Application Dilution: WB: 1:500 - 1:2000, IHC: 1:50 - 1:200
Specificity: NEDD4 polyclonal antibody detects endogenous levels of NEDD4 protein.
Immunogen:
Recombinant protein of human NEDD4.
MW: ~ 149 kDa
Swis Prot.: P46934
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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