NEDD4 Polyclonal Antibody

Background:
This gene is the founding member of the NEDD4 family of HECT ubiquitin ligases that function in the ubiquitin proteasome system of protein degradation. The encoded protein contains an N-terminal calcium and phospholipid binding C2 domain followed by multiple tryptophan-rich WW domains and, a C-terminal HECT ubiquitin ligase catalytic domain. It plays critical role in the regulation of a number of membrane receptors, endocytic machinery components and the tumor suppressor PTEN.

Research Area: Cancer, Cell Biology, Epigenetics and Nuclear Signaling, Neuroscience

Synonyms:
NEDD4, NEDD4-1, RPF1

Immunogen: Recombinant fusion protein of human NEDD4 (NP_940682.2).

Swissprot: P46934
Gene ID: 4734

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Concentration: 1 mg/mL
Dilution: IHC 1:50-1:200

Storage:
Store at -20°C. Avoid freeze / thaw cycles.