NEDD4L Polyclonal Antibody

Background:
This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein mediates the ubiquitination of multiple target substrates and plays a critical role in epithelial sodium transport by regulating the cell surface expression of the epithelial sodium channel, ENaC. Single nucleotide polymorphisms in this gene may be associated with essential hypertension. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Research Area: Cancer, Cell Biology, Epigenetics and Nuclear Signaling

Synonyms:
NEDD4L, NEDD4-2, NEDD4.2, PVNH7, RSP5, hNEDD4-2

Immunogen: Recombinant fusion protein of human NEDD4L (NP_056092.2).

Swissprot: Q96PU5
Gene ID: 23327

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Concentration: 1 mg/mL
Dilution: "IHC 1:50-1:200 IF 1:50-1:200"

Storage:
Store at -20°C. Avoid freeze / thaw cycles.