NEDD4L polyclonal (Center), anti-mouse
€0.00
In stock
SKU
AC-AP14949C
Catalog Number: AC-AP14949C
Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB34399
Applications: WB
Datasheet
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Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB34399
Applications: WB
Datasheet
Request Information
Background:
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Inhibits TGF-beta signaling by triggering SMAD2 and TGFR1 ubiquitination and proteasome-dependent degradation. Promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, Nav1.2, Nav1.3, Nav1.5, Nav1.7, Nav1.8, Kv1.3, EAAT1 or CLC5. Promotes ubiquitination and degradation of SGK.
Other Names:
E3 ubiquitin-protein ligase NEDD4-like, 632-, NEDD42, Nedd4-2, NEDD4L, KIAA0439, NEDL3
Target/Specificity:
This NEDD4L antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 576-604 amino acids from the Central region of human NEDD4L.
Antigen Region:
576-604
Antigen Type: Synthetic Peptide
Gene Name: NEDD4L {ECO:0000303|PubMed:11840194}
Gene ID: 23327
Primary Accession: Q96PU5
NCBI Accession: NP_001138436.1;NP_001138437.1;NP_001138438.1;NP_001138439.1;NP_001138440.1;NP_001138441.1;NP_001138442.1;NP_001138443.1;NP_001230889.1;NP_056092.2
Other Accession: Q8CFI0; NP_001138436.1; NP_001138442.1; NP_001138439.1
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Inhibits TGF-beta signaling by triggering SMAD2 and TGFR1 ubiquitination and proteasome-dependent degradation. Promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, Nav1.2, Nav1.3, Nav1.5, Nav1.7, Nav1.8, Kv1.3, EAAT1 or CLC5. Promotes ubiquitination and degradation of SGK.
Other Names:
E3 ubiquitin-protein ligase NEDD4-like, 632-, NEDD42, Nedd4-2, NEDD4L, KIAA0439, NEDL3
Target/Specificity:
This NEDD4L antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 576-604 amino acids from the Central region of human NEDD4L.
Antigen Region:
576-604
Antigen Type: Synthetic Peptide
Gene Name: NEDD4L {ECO:0000303|PubMed:11840194}
Gene ID: 23327
Primary Accession: Q96PU5
NCBI Accession: NP_001138436.1;NP_001138437.1;NP_001138438.1;NP_001138439.1;NP_001138440.1;NP_001138441.1;NP_001138442.1;NP_001138443.1;NP_001230889.1;NP_056092.2
Other Accession: Q8CFI0; NP_001138436.1; NP_001138442.1; NP_001138439.1
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
| Is Featured? | No |
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