NEFH Polyclonal Antibody

Background:
Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and functionally maintain neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the heavy neurofilament protein. This protein is commonly used as a biomarker of neuronal damage and susceptibility to amyotrophic lateral sclerosis (ALS) has been associated with mutations in this gene.

Research Area: Cancer, Neuroscience, Signal transduction

Synonyms:
CMT2CC, NFH, NEFH

Immunogen: Recombinant fusion protein of human NEFH (NP_066554.2).

Swissprot: P12036
Gene ID: 4744

Calculated MW: 105 kDa/112 kDa
Observed MW: 240 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Concentration: 1 mg/mL
Dilution: "WB 1:500-1:2000 IHC 1:50-1:100 IF 1:50-1:100"

Storage:
Store at -20°C. Avoid freeze / thaw cycles.