NEFL Polyclonal Antibody

Background:
Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and they functionally maintain the neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the light chain neurofilament protein. Mutations in this gene cause Charcot-Marie-Tooth disease types 1F (CMT1F) and 2E (CMT2E), disorders of the peripheral nervous system that are characterized by distinct neuropathies. A pseudogene has been identified on chromosome Y.

Research Area: Cancer, Developmental Biology, Neuroscience, Signal Transduction, Stem Cells

Synonyms:
NEFL, CMT1F, CMT2E, NF-L, NF68, NFL, PPP1R110

Immunogen: Recombinant fusion protein of human NEFL (NP_006149.2).

Swissprot: P07196
Gene ID: 4747

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Concentration: 1 mg/mL
Dilution: "IHC 1:50-1:200 IF 1:50-1:200"

Storage:
Store at -20°C. Avoid freeze / thaw cycles.