Nesprin 1 polyclonal, anti-human, mouse, rat

Background:
Multi-isomeric modular protein which forms a linking network between organelles and the actin cytoskeleton to maintain the subcellular spatial organization. As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. May be involved in nucleus-centrosome attachment and nuclear migration in neural progenitors implicating LINC complex association with SUN1/2 and probably association with cytoplasmic dynein-dynactin motor complexes, SYNE1 and SYNE2 may act redundantly. Required for centrosome migration to the apical cell surface during early ciliogenesis. May be involved in nuclear remodeling during sperm head formation in spermatogenenis, a probable SUN3:SYNE1/KASH1 LINC complex may tether spermatid nuclei to posterior cytoskeletal structures such as the manchette.

Alternative Name:
KASH1, Myne-1, Syne-1, SYNE1, C6orf98, KIAA0796, KIAA1262, KIAA1756, MYNE1, 8B, ARCA1, C6orf98, CPG2, CPG2 full length, dJ45H2.2, EDMD4, Enaptin, Myne-1, MYNE1, Myocyte nuclear envelope protein 1, Nesp1, Nesprin-1, Nuclear envelope spectrin repeat protein 1, SCAR8, Spectrin repeat containing nuclear envelope 1, Synaptic nuclear envelope protein 1, Synaptic nuclei expressed gene 1, Syne-1, SYNE1, SYNE1, SYNE1B,

Application Dilution:
WB:1:500-1:2,000
ICC:1:200-1:1,000
IHC:1:50-1:200
FC:1:50-1:100

Specificity: Nesprin 1 polyclonal antibody detects endogenous levels of Nesprin 1 protein.

Immunogen:
Recombinant protein

MW: 112 kDa

Swiss-Prot: Q8NF91(Human) Q6ZWR6(Mouse)

Purification & Purity:
ProA affinity purified

Format:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Storage:
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

For research use only, not for use in diagnostic procedure.