CXADR polyclonal, anti-human, mouse, rat
€470.00
In stock
SKU
AC-AP51754
Catalog Number: AC-AP54700
Size: 100 µl
Host: Rabbit
Applications: IHC-P, IHC-F, IF, ICC, E
Datasheet
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Size: 100 µl
Host: Rabbit
Applications: IHC-P, IHC-F, IF, ICC, E
Datasheet
Request Information
Background:
Component of the epithelial apical junction complex that may function as an homophilic cell adhesion molecule and is essential for tight junction integrity. Also involved in transepithelial migration of leukocytes through adhesive interactions with AMICA1/JAML a transmembrane protein of the plasma membrane of leukocytes. The interaction between both receptors also mediates the activation of gamma-delta T cells, a subpopulation of T cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, AMICA1 induces downstream cell signaling events in gamma-delta T cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T cells that in turn stimulate epithelial tissues repair.
Other Names:
Coxsackievirus and adenovirus receptor, CAR, hCAR, CVB3-binding protein, Coxsackievirus B-adenovirus receptor, HCVADR, CXADR, CAR
Antigen Type: synthetic peptide
Antigen Type: CXADR
Gene ID: 1525
Primary Accession: P78310
Component of the epithelial apical junction complex that may function as an homophilic cell adhesion molecule and is essential for tight junction integrity. Also involved in transepithelial migration of leukocytes through adhesive interactions with AMICA1/JAML a transmembrane protein of the plasma membrane of leukocytes. The interaction between both receptors also mediates the activation of gamma-delta T cells, a subpopulation of T cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, AMICA1 induces downstream cell signaling events in gamma-delta T cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T cells that in turn stimulate epithelial tissues repair.
Other Names:
Coxsackievirus and adenovirus receptor, CAR, hCAR, CVB3-binding protein, Coxsackievirus B-adenovirus receptor, HCVADR, CXADR, CAR
Antigen Type: synthetic peptide
Antigen Type: CXADR
Gene ID: 1525
Primary Accession: P78310
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