Neurocalcin δ rabbit polyclonal, anti-human, mouse, rat

Backgroud: This gene encodes a member of the neuronal calcium sensor (NCS) family of calcium-binding proteins. The protein contains an N-terminal myristoylation signal and four EF-hand calcium binding loops. The protein is cytosolic at resting calcium levels; however, elevated intracellular calcium levels induce a conformational change that exposes the myristoyl group, resulting in protein association with membranes and partial co-localization with the perinuclear trans-golgi network. The protein is thought to be a regulator of G protein-coupled receptor signal transduction. Several alternatively spliced variants of this gene have been determined, all of which encode the same protein; additional variants may exist but their biological validity has not been determined. [provided by RefSeq, Jul 2008],function:May be involved in the calcium-dependent regulation of rhodopsin phosphorylation. Binds three calcium ions.,similarity:Belongs to the recoverin family.,similarity:Contains 4 EF-hand domains.,tissue specificity:Retina, cerebrum, cerebellum, brain stem, spinal cord, testis, ovary and small intestine.,

Synonyms: NCALD, Neurocalcin-delta

Gene Name: NCALD

Gene ID: 83988

SwissProt ID: P61601

Purification: Affinity purification

Storage: Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.