Neurocan polyclonal, anti-human, mouse, rat
€305.00
In stock
SKU
BS5819
Background:
The lecticans are a family of chondroitin proteoglycans, including aggrecan, versican, neurocan and brevican, that contain a C-type lectin domain. Neurocan is a glycoprotein synthesized primarily by neurons, and its expression levels are highest during embryonic brain development and during the early postnatal period. Neurocan is a component of the extracellular matrix in the central nervous system that can bind to various other CNS matrix components, such as heparin, Tenascin-R, HB-GAM and NCAM, suggesting that it plays a role in axon guidance and neurite growth. Neurocan is a 1,257 amino acid, precursor protein in embryonic and neonatal rats that is proteolytically proc-essed in the adult CNS into an N-terminal fragment, which localizes to the cytoplasm of glial cells. Neurocan expression (including the re-expression of the neonatal isoform) increases significantly in adults in the glial scar resulting from cortical injury.
Alternative Name:
Neurocan core protein, Chondroitin sulfate proteoglycan 3, NCAN, CSPG3, NEUR
Application Dilution: WB: 1:500~1:1000
Specificity: Neurocan polyclonal antibody detects endogenous levels of Neurocan protein.
Immunogen:
Synthetic peptide, corresponding to amino acids 440-485 of Human Neurocan.
MW: ~ 220 kDa (Full length), 140 kDa (Proteolytic variant)
Swis Prot.: O14594
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
The lecticans are a family of chondroitin proteoglycans, including aggrecan, versican, neurocan and brevican, that contain a C-type lectin domain. Neurocan is a glycoprotein synthesized primarily by neurons, and its expression levels are highest during embryonic brain development and during the early postnatal period. Neurocan is a component of the extracellular matrix in the central nervous system that can bind to various other CNS matrix components, such as heparin, Tenascin-R, HB-GAM and NCAM, suggesting that it plays a role in axon guidance and neurite growth. Neurocan is a 1,257 amino acid, precursor protein in embryonic and neonatal rats that is proteolytically proc-essed in the adult CNS into an N-terminal fragment, which localizes to the cytoplasm of glial cells. Neurocan expression (including the re-expression of the neonatal isoform) increases significantly in adults in the glial scar resulting from cortical injury.
Alternative Name:
Neurocan core protein, Chondroitin sulfate proteoglycan 3, NCAN, CSPG3, NEUR
Application Dilution: WB: 1:500~1:1000
Specificity: Neurocan polyclonal antibody detects endogenous levels of Neurocan protein.
Immunogen:
Synthetic peptide, corresponding to amino acids 440-485 of Human Neurocan.
MW: ~ 220 kDa (Full length), 140 kDa (Proteolytic variant)
Swis Prot.: O14594
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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