Neuropeptide Y 1-20 polyclonal, anti-human, rat, hamster, mouse

Quantity: 100 µl

Background:
Neuropeptide Y (NPY) is a 36-amino acid neuropeptide that acts as a neurotransmitter in the brain and in the autonomic nervous system of humans. In the autonomic system it is mainly produced by neurons of the sympathetic nervous system and serves as a strong vasoconstrictor and also causes growth of fat tissue. In the brain it is produced in various locations including the hypothalamus, and is thought to have several functions, including: increasing food intake and storage of energy as fat, reducing anxiety and stress, reducing pain perception, affecting the circadian rhythm, reducing voluntary alcohol intake, lowering blood pressure and controlling epileptic seizures.

Synonyms:
NPY, PYY

Isotype: Rabbit Polyclonal

Immunogen:
Synthetic cys(21)-NPY 1-21, conjugated to BSA

Form: Serum containing 0.1% sodium azide

Specificity:
Absorption with 10-100 ?g NPY 1-20 per ml diluted antiserum abolishes the staining, while PYY and PP do not.

Reactivity: human, rat, hamster, mouse

Applications: Immunofluorescence, suitable for frozen sections

Working DIlution: 1:10 – 1:20 for immunofluorescence microscopy

Positive Control:
Stefanini-fixed sections of rat small intestine

Storage: 2-8C for immediate use, or at -20C (aliquot)

References:
- Ahre?n B et al. (1999) J Diab Comp 12: 321-327
- Myrse?n U et al. (1995) RegulPept 57: 65-76
- Myrse?n U et al. (1995) Regul Pept 60: 19-31
- Jackerott M et al. (1996) J Histochem Cytochem 44 (8): 809-817