Neuropilin-1 polyclonal, anti-human, mouse, rat

Background:
Neuropilin is a type I transmembrane receptor that has been implicated in aspects of axon growth and guidance and has been shown to act as a high affinity receptor for class III semaphorins and vascular endothelial growth factor (VEGF). A closely related protein, neuropilin-2, shares a common domain structure and signifcant homology with neuropilin and also acts as a receptor for the class III semaphorins and VEGF. Both neuropilins are involved in regulating many physiological pathways including axonal guidance and angiogenesis, however they exhibit differential expression in the adult vasculature. Neuropilin-2 is polysialylated and expressed on the surface of dendritic cells. It is also expressed by venous and lymphatic endothelium. Neuropilin is expressed predominantly by arterial endothelium.

Alternative Name:
NRP1, NRP, VEGF165R, A5 protein, BDCA4, BLOOD DENDRITIC CELL ANTIGEN 4, CD304, Neuropilin-1, Neuropilin1, NP1, NPN1, NRP 1, NRP, NRP1, NRP1, transmembrane receptor, Vascular endothelial cell growth factor 165 receptor, VEGF165R,

Application Dilution:
WB:1:1,000-1:5,000
ICC:1:50-1:200
IHC:1:50-1:200
FC:1:50-1:100

Specificity: Neuropilin-1 polyclonal antibody detects endogenous levels of Neuropilin-1 protein.

Immunogen:
recombinant protein

MW: 120 kDa

Swiss-Prot: O14786(Human) P97333(Mouse) Q9QWJ9(Rat)

Purification & Purity:
ProA affinity purified

Format:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Storage:
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

For research use only, not for use in diagnostic procedure.