Neuroserpin polyclonal, anti-human

Background:
This gene encodes a member of the serpin superfamily of serine proteinase inhibitors. The protein is primarily secreted by axons in the brain, and preferentially reacts with and inhibits tissue-type plasminogen activator. It is thought to play a role in the regulation of axonal growth and the development of synaptic plasticity. Mutations in this gene result in familial encephalopathy with neuroserpin inclusion bodies (FENIB), which is a dominantly inherited form of familial encephalopathy and epilepsy characterized by the accumulation of mutant neuroserpin polymers. Multiple alternatively spliced variants, encoding the same protein, have been identified.

Other Names:
Neuroserpin, Peptidase inhibitor 12, PI-12, Serpin I1, SERPINI1, PI12

Antigen Types:
Synthetic Peptide

Gene Name:
SERPINI1
Gene ID:
5274
Primary Accession: Q99574
Other Accession: NP_001116224;5274;