Neurotensin polyclonal, anti-human, rat, cat, bovine, amphibia

Quantity: 100 µl

Background:
This gene encodes a common precursor for two peptides, neuromedin N and neurotensin. Neurotensin is a secreted tridecapeptide, which is widely distributed throughout the central nervous system, and may function as a neurotransmitter or a neuromodulator. It may be involved in dopamine-associated pathophysiological events, in the maintenance of gut structure and function, and in the regulation of fat metabolism. Tissue-specific processing may lead to the formation in some tissues of larger forms of neuromedin N and neurotensin. The large forms may represent more stable peptides that are also biologically active.

Synonyms:
NTS, NN, NT, NT/N, NTS1, NMN-125

Isotype: Rabbit Polyclonal

Immunogen:
Synthetic bovine neurotensin

Form: Serum containing 0.1% sodium azide

Specificity:
The antibody can be used to discriminate tumors derived from endocrine cells of the lieum and adrenal medulla.

Reactivity: human, rat, cat, bovine, amphibia

Applications: Immunohistochemistry of frozen and paraffin-embedded sections (no protease treatment required)

Working DIlution: 1:10 to 1:25 for immunohistochemistry

Positive Control:
Ileum

Storage: 2-8C for immediate use, or at -20C (aliquot)

References:
- Maake C et al. (1999) Cell Tissue Res 297: 91-101
- Karila P et al. (1995) Regul Peptides 58: 25-29
- Larsson L et al. (1990) Arch A Pathol Anat 416: 465-475