Neurotrophin-3 polyclonal, anti-human, mouse, rat, bovine, dog, hamster, monkey

Protein Family: Cytokines

Pathway and Disease: Nervous and Sensory Systems, Signal Transduction

Description:
Neurotrophin-3 (NT-3) is a neurotrophic factor in the NGF family of neurotrophins. NT-3 has activity on certain neurons of the peripheral and central nervous systems, supporting survival and differentiation of existing and new neurons. Neurotrophins function primarily to regulate naturally occurring cell death of neurons during development. Two additional structurally homologous neurotrophic factors have been identified: brain-derived neurotrophic factor (BDNF) and neurotrophic 4 (NT-4), also designated NT-5.

Alternate Names: Neurotrophin-3, NT-3, Neurotrophic factor, HDNF, Nerve growth factor 2, NGF-2, NTF3

Application Notes: E: 1:500-1:1,000; WB: 1: 200-1:500; IHC: 1:200-1:500

Accession No.: P20783

Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human NT-3.

Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.

Product Citations:
[1] Matyal R et al. 2014. Ann Thorac Surg. 98(5): 1635-43. PMID# 25258156.
[2] Renault M et al. 2013. Circulation Research. Doi: 11.1161/circresaha.113.300871. PMID# 23343527.