NF2/Merlin (phospho-S518) polyclonal, anti-human, mouse, rat
€328.00
In stock
SKU
BS4800
Background:
Neurofibromin 2 (NF2) is a tumor suppressor gene encoding the protein Merlin. Merlin is closely related to the ERM (ezrin, radixin, moesin) family of proteins. The precise funtion of Merlin is not clear. It is thought to provide a link between the actin cytoskeleten and membrane associated proteins, playing a role in transduction of extracellular signals. It has been implicated in cell proliferation and cellular motility. Mutations in the NF2 gene cause neurofibromatosis type II, a condition characterised by the development of tumors in the central nervous system.
Alternative Name:
Merlin, Moesin-ezrin-radixin-like protein, Neurofibromin-2, Schwannomerlin, Schwannomin, NF2, SCH
Application Dilution: WB: 1:500~1:1000, IF: 1:200
Specificity: p-NF2/Merlin (S518) polyclonal antibody detects endogenous levels of NF2/Merlin protein only when phosphorylated at Ser518
Immunogen:
Synthetic phosphopeptide derived from human Merlin around the phosphorylation site of Serine 518.
MW: ~ 70 kDa
Swis Prot.: P35240
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
Neurofibromin 2 (NF2) is a tumor suppressor gene encoding the protein Merlin. Merlin is closely related to the ERM (ezrin, radixin, moesin) family of proteins. The precise funtion of Merlin is not clear. It is thought to provide a link between the actin cytoskeleten and membrane associated proteins, playing a role in transduction of extracellular signals. It has been implicated in cell proliferation and cellular motility. Mutations in the NF2 gene cause neurofibromatosis type II, a condition characterised by the development of tumors in the central nervous system.
Alternative Name:
Merlin, Moesin-ezrin-radixin-like protein, Neurofibromin-2, Schwannomerlin, Schwannomin, NF2, SCH
Application Dilution: WB: 1:500~1:1000, IF: 1:200
Specificity: p-NF2/Merlin (S518) polyclonal antibody detects endogenous levels of NF2/Merlin protein only when phosphorylated at Ser518
Immunogen:
Synthetic phosphopeptide derived from human Merlin around the phosphorylation site of Serine 518.
MW: ~ 70 kDa
Swis Prot.: P35240
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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