NF2 polyclonal, anti-human

Background:
This gene encodes a protein that is similar to some members of the ERM (ezrin, radixin, moesin) family of proteins that are thought to link cytoskeletal components with proteins in the cell membrane. This gene product has been shown to interact with cell-surface proteins, proteins involved in cytoskeletal dynamics and proteins involved in regulating ion transport. This gene is expressed at high levels during embryonic development; in adults, significant expression is found in Schwann cells, meningeal cells, lens and nerve. Mutations in this gene are associated with neurofibromatosis type II which is characterized by nervous system and skin tumors and ocular abnormalities. Two predominant isoforms and a number of minor isoforms are produced by alternatively spliced transcripts.

Synonyms: ACN, BANF, SCH

Cellular Location: Cell projection Cytoplasm Cytoplasmic granule Cytoplasmic side Nucleus Nucleus Peripheral membrane protein cytoskeleton filopodium membrane perinuclear region ruffle membrane

Immunogen:
Recombinant protein of human NF2

Gene Symbol: NF2

Gene ID: 4771

Swiss prot: P35240

Calculated MW: 70kDa

Recommended dilution:
WB 1:500-2000 IF 1:20-100, IHC 1:50-200,

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Storage:
Store at -20℃. Avoid freeze / thaw cycles.