NF2 Polyclonal Antibody

Background:
This gene encodes a protein that is similar to some members of the ERM (ezrin, radixin, moesin) family of proteins that are thought to link cytoskeletal components with proteins in the cell membrane. This gene product has been shown to interact with cell-surface proteins, proteins involved in cytoskeletal dynamics and proteins involved in regulating ion transport. This gene is expressed at high levels during embryonic development; in adults, significant expression is found in Schwann cells, meningeal cells, lens and nerve. Mutations in this gene are associated with neurofibromatosis type II which is characterized by nervous system and skin tumors and ocular abnormalities. Two predominant isoforms and a number of minor isoforms are produced by alternatively spliced transcripts.

Research Area: Cancer, Epigenetics and Nuclear Signaling, Neuroscience, Signal Transduction

Synonyms:
ACN, BANF, Bilateral acoustic neuroma, MERL, Merlin, Moesin ezrin radixin like protein, Moesin ezrin radizin like, Moesin-ezrin-radixin-like protein, Neurofibromatosis 2, Neurofibromatosis type 2, Neurofibromatosis2, Neurofibromin 2, Neurofibromin-2, Neurofibromin2, NF 2, Nf2, SCH, Schwannomerlin, Schwannomin

Immunogen: Recombinant Human Merlin protein

Swissprot: P35240

Purification Method: Affinity purification

Buffer: PBS with 0.05% Proclin300 and 50% glycerol, pH7.4.

Concentration: 2 mg/mL
Dilution: IHC 1:100-1:200

Storage:
Store at -20°C. Avoid freeze / thaw cycles.