NFAT2 polyclonal, anti-human

Quantity: 100 µg

Background:
NFATC1(Nuclear factor of activated T-cells, cytoplasmic 1), also known as NFATC or NFAT2, is a protein that in humans is encoded by the NFATC1 gene. And it is also a component of the nuclear factor of activated T cells DNA-binding transcription complex. The NFATC1 gene is mapped on 18q23. Proteins belonging to this family of transcription factors play a central role in inducible gene transcription during immune response. NFATC1 was not detected in brain, liver, or kidney. NFATC1 is an inducible nuclear component which functions as a major molecular target for the immunosuppressive drugs such as cyclosporin A. The solution structure of the binary complex formed between the core DNA-binding domain of human NFATC1 and the 12-bp oligonucleotide duplex containing the ARRE2 DNA site from the IL2 promoter. Nfatc1 was expressed exclusively in mouse hair follicle stem cells, and using gain- and loss-of-function approaches, and Nfatc1 inhibited stem cell activation.

Description:
Rabbit IgG polyclonal antibody for Nuclear factor of activated T-cells, cytoplasmic 1 (NFATC1) detection. Tested with WB in Human.

Synonyms:
cytoplasmic 1 antibody, MGC138448 antibody, NAFATC antibody, NF ATc antibody, NF ATc1 antibody, NF-ATc antibody, NF-ATc1 antibody, NFAC1_HUMAN antibody, NFAT 2 antibody, NFAT transcription complex cytosolic component antibody, NFAT2 antibody, NFATC 1 antibody, NFATc antibody, NFATC1 antibody, Nuclear factor of activated T cells cytoplasmic 1 antibody, Nuclear factor of activated T cells cytoplasmic calcineurin dependent 1 antibody, Nuclear factor of activated T cells cytosolic component 1 antibody, Nuclear factor of activated T-cells antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
A synthetic peptide corresponding to a sequence at the C-terminus of human NFAT2(700-716aa AIFLTVSREHERVGCFF).

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human

Applications: WB

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.