NFAT2 Polyclonal Antibody

Background:
The product of this gene is a component of the nuclear factor of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation, and an inducible nuclear component. Proteins belonging to this family of transcription factors play a central role in inducible gene transcription during immune response. The product of this gene is an inducible nuclear component. It functions as a major molecular target for the immunosuppressive drugs such as cyclosporin A. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Different isoforms of this protein may regulate inducible expression of different cytokine genes.

Research Area: Cancer, Cardiovascular, Epigenetics and Nuclear Signaling, Immunology, Signal Transduction

Synonyms:
NF-ATC, NF-ATc1.2, NFAT2, NFATc, NFATC1

Immunogen: Recombinant fusion protein of human NFAT2 (NP_765978.1).

Swissprot: O95644
Gene ID: 4772

Calculated MW: 38 kDa/74- 88 kDa/100-101 kDa
Observed MW: 78 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Concentration: 1 mg/mL
Dilution: "WB 1:500-1:3000 IHC 1:50-1:200"

Storage:
Store at -20°C. Avoid freeze / thaw cycles.