NFE4 Blocking Peptide (C-term)
€363.00
In stock
SKU
AC-BP21375b
Background:
Functions as part of the SSP (stage selector protein) complex, a complex that contributes to the preferential expression of the gamma-gene in fetal erythroid cells by facilitating the interaction of the gamma-globin genes with enhancer elements contained in the locus control region (LCR). The complex binds to the stage selector element (SSE) in the proximal gamma-globin promoter. In contrast, isoform 2 acts as a repressor of gamma- globin gene expression by preventing NFE2 and RNA polymerase II recruitment to the promoter.
Other Names:
Transcription factor NF-E4, NFE4
Target/Specificity:
The synthetic peptide sequence is selected from aa 135-149 of HUMAN NFE4
Gene Name: NFE4
Primary Accession: Q86UQ8
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Functions as part of the SSP (stage selector protein) complex, a complex that contributes to the preferential expression of the gamma-gene in fetal erythroid cells by facilitating the interaction of the gamma-globin genes with enhancer elements contained in the locus control region (LCR). The complex binds to the stage selector element (SSE) in the proximal gamma-globin promoter. In contrast, isoform 2 acts as a repressor of gamma- globin gene expression by preventing NFE2 and RNA polymerase II recruitment to the promoter.
Other Names:
Transcription factor NF-E4, NFE4
Target/Specificity:
The synthetic peptide sequence is selected from aa 135-149 of HUMAN NFE4
Gene Name: NFE4
Primary Accession: Q86UQ8
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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