NFIB NF1B2 (clone ), anti-human, mouse, rat

Background:
NF-1, also designated CTF, consists of a family of CCAAT box binding proteins that stimulate DNA replication and activate transcription. Analysis of human NF-1 messenger RNA has revealed two forms of the NF-1 protein arising from an alternate splicing of a single NF-1 gene. NF-1 binds its consensus DNA element as a homodimer via an amino-terminal DNA binding domain, and activates transcription through a putatively novel, proline-rich, carboxy terminal transactivation domain. The NF-1 protein has been shown to recognize and bind the adenovirus type 2 promoter and activate transcription of herpes simplex virus thymidine kinase genes. The NF-1 consensus element has been found in the upstream promoter region of myriad eukaryotic genes, including that of Ha-Ras, α-globin, HSP 70, GRP 78, Histone H1, myelin basic protein and in the Xenopus laevis vitellogenin gene promoter.

Alternative Name:
NF1-B, Nuclear factor 1/B, CTF, NF-I/B, NFI-B, NFIB, CCAAT Box Binding Transcription Factor, CCAAT-box-binding transcription factor, CTF, HMGIC/NFIB, NF-I/B, NF1-B, NF1B, NF1B2, NFI-B, NFI-RED, Nfib, NFIB, NFIB2, NFIB3, Nuclear factor 1 B-type, Nuclear factor 1/B, Nuclear Factor 1B, Nuclear Factor I B, Nuclear factor I/B, TGGCA Binding Protein, TGGCA-binding protein, TRANSCRIPTION FACTOR NFIB,

Application Dilution:
WB:1:500-1:1,000
IHC:1:50-1:200
FC:1:50-1:100

Specificity: NFIB NF1B2 monoclonal antibody detects endogenous levels of NFIB NF1B2 protein.

Immunogen:
Recombinant full length protein corresponding to human NFIB/NF1B2.

MW: 47 kDa

Swiss-Prot: O00712(Human) P97863(Mouse)

Purification & Purity:
ProG affinity purified.

Format:
Mouse IgG2b, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Storage:
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.

For research use only, not for use in diagnostic procedure.