NFkB p100 polyclonal, anti-human, mouse, rat

Background:
NFKB2 appears to have dual functions such as cytoplasmic retention of attached NF-kappa-B proteins by p100 and generation of p52 by a cotranslational processing. The proteasome-mediated process ensures the production of both p52 and p100 and preserves their independent function. p52 binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3', located in the enhancer region of genes involved in immune response and acute phase reactions. p52 and p100 are respectively the minor and major form, the processing of p100 being relatively poor. Isoform p49 is a subunit of the NF-kappa-B protein complex, which stimulates the HIV enhancer in synergy with p65.

Alternative Name:
Lyt10, NFKB2, LYT10, CVID10, DNA binding factor KBF2, H2TF1, Lymphocyte translocation chromosome 10 protein, LYT 10, NF kB2, NFKB p52/p100 subunit, Nuclear factor Kappa B subunit 2, Nuclear factor of kappa light polypeptide gene enhancer in B cells 2 (p49/p100), Nuclear factor of kappa light polypeptide gene enhancer in B cells 2, Oncogene Lyt 10, p100, Transcription factor NFKB2,

Application Dilution:
WB:1:500-1:2,000
ICC:1:50-1:200
IHC:1:50-1:200

Specificity: NFkB p100 polyclonal antibody detects endogenous levels of NFkB p100 protein.

Immunogen:
Recombinant protein

MW: 100 kDa

Swiss-Prot: Q00653(Human) Q9WTK5(Mouse)

Purification & Purity:
ProA affinity purified

Format:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Storage:
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

For research use only, not for use in diagnostic procedure.