NFKB(p105) Antibody (C-term S933) Blocking Peptide
€363.00
In stock
SKU
AC-BP19121b
Background:
This gene encodes a 105 kD protein which can undergocotranslational processing by the 26S proteasome to produce a 50 kDprotein. The 105 kD protein is a Rel protein-specific transcriptioninhibitor and the 50 kD protein is a DNA binding subunit of theNF-kappa-B (NFKB) protein complex. NFKB is a transcriptionregulator that is activated by various intra- and extra-cellularstimuli such as cytokines, oxidant-free radicals, ultravioletirradiation, and bacterial or viral products. Activated NFKBtranslocates into the nucleus and stimulates the expression ofgenes involved in a wide variety of biological functions.Inappropriate activation of NFKB has been associated with a numberof inflammatory diseases while persistent inhibition of NFKB leadsto inappropriate immune cell development or delayed cell growth.Two transcript variants encoding different isoforms have been foundfor this gene.
Other Names:
Nuclear factor NF-kappa-B p105 subunit, DNA-binding factor KBF1, EBP-1, Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, Nuclear factor NF-kappa-B p50 subunit, NFKB1
Gene Name: NFKB1
Gene ID: 4790
Primary Accession: P19838
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
This gene encodes a 105 kD protein which can undergocotranslational processing by the 26S proteasome to produce a 50 kDprotein. The 105 kD protein is a Rel protein-specific transcriptioninhibitor and the 50 kD protein is a DNA binding subunit of theNF-kappa-B (NFKB) protein complex. NFKB is a transcriptionregulator that is activated by various intra- and extra-cellularstimuli such as cytokines, oxidant-free radicals, ultravioletirradiation, and bacterial or viral products. Activated NFKBtranslocates into the nucleus and stimulates the expression ofgenes involved in a wide variety of biological functions.Inappropriate activation of NFKB has been associated with a numberof inflammatory diseases while persistent inhibition of NFKB leadsto inappropriate immune cell development or delayed cell growth.Two transcript variants encoding different isoforms have been foundfor this gene.
Other Names:
Nuclear factor NF-kappa-B p105 subunit, DNA-binding factor KBF1, EBP-1, Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, Nuclear factor NF-kappa-B p50 subunit, NFKB1
Gene Name: NFKB1
Gene ID: 4790
Primary Accession: P19838
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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